Bioperine is an extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) that contains 95 percent of piperine. Black pepper is a common household spice. Extract from black pepper has also been used extensively as a medicine. To reach the greatest quality during the harvest, the pepper is reaped before ripening and after that is placed to dry under the sun rays. Bioperine is known for its effect to enhance the efficiency of many supplement nutrients. Bioperine acts to enhance the body’s natural therogenic activity – giving the name thermonutrient. This enhancement brings about increased metabolic rate creating demand for supple of many nutrients such as vitamins, minerals, herbals, amino acids. It sets in motion a process that brings about better digestion and faster gastrointestinal absorption.

Citric Acid ~

Cyclic Adenosine Monophosphate 3'-5'-cyclic adenosine monophosphate or Cyclic Adenosine Monophosphate, a second messenger that mediates the action of several eptide or amine hormones, is abbreviated as cyclic AMP or cAMP. cAMP is thus vital for varied biological processes and used for intracellular signal transduction in various organisms. This major communicator is a result of the action of the enzyme adenyl cyclase on ATP. As such, cyclic AMP performs many physiological functions and is also responsible for increasing blood glucose levels. Adrenaline that enhances blood sugar levels in the body is able to do so by stimulating cAMP production. Cyclic AMP plays an important role in the following: urine regulation synthesis of flagellar proteins in bacteria hormone release sensory and nerve processes Apart from these functions, it also helps in breakdown of lipids in some organisms to produce energy in the absence of sufficient glucose.

Dioscorea Villosa extract is a medicinal herb commonly knows as the wild yam. It has medicinal properties that help in curing the pain caused during menstrual cycle, stomach cramps, and discomfort from gallstones and rheumatoid arthritis. It has been used fro centuries by the Native Americans. It is also used by herbalists for female and childbirth related problems. Along with herbal medicine, this plant is of great use in the modern medicine as well. It is because of this plant that birth control pills are so commonly and easily available. Its steroid like property explains the vast usage of this plant for medicinal purposes. But consumption of this extract may also lead to a number of side effects. Vomiting, diarrhea, nausea and headache are some of the most common side effects of dioscorea villosa extract.

Evodiamine- Tetradii Fructus, the fruit of the evodia plant, also known as Tetradium rutaecarpa, contains an active element that has recently been identified as evodiamine. This chemical compound is believed to be somewhat similar to capsaicin, the active compound found in the chili peppers. Some studies suggested that this vanilloid receptor agonist may interact with thermogenin, otherwise known as the uncoupling protein 1, UCP1, which is able to generate heat by a mechanism called thermogenesis. Tetradium rutaecarpa has been traditionally used in Chinese medicine for weight loss purposes and current studies seem to verify this information. Evodiamine has been embraced as a dietary supplement directed at weight loss, predominantly by the body building circles. This supplement is deemed to have energy burning and fat reducing, as well as diuretic properties.

Glabra, commonly known as licorice, is a root used to extract a sweet flavor from. Licorice is a plant belonging to the legume family, like peas and beans. It takes two to three years after planting for licorice to be harvested in autumn. It requires deep, fertile, well drained soil with a lot of sun to be able to grow. The extract from licorice is produced by boiling the roots with water and then evaporating all the water. This extract is then sold both in the form of solid and liquid. Glabra consists of a sweetener called glycyrrhizin which is many times sweeter than sucrose. It is used in lot cough syrups and in ayurvedic medicine. Candies made from licorice roots are famous all over the world. Hence it is in many pharmaceutical and confectionery products.

Guggulsterone is a plant sterol found in the resin of the guggul plant, Commiphora mukul. It acts as an antagonist of the farnesoid X receptor, which was earlier believed to result in decreased cholesterol synthesis in the liver.

L-Tyrosine is a non-essential amino acid, which is used by the cells in order to synthesize the proteins and appears to help stabilize ones mood during periods of high stress levels.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Phosphatidylcholine - a major component of biological membranes and can be isolated from egg yolk or soy beans. This extraction of the Phosphatidylcholine is done using hexane. Phosphatidylcholine is in fact a primary dietary source of choline, an essential nutrient which can also be synthesised by the body. Phosphatidylcholine is composed of a phosphate group, 2 fatty acids and choline. The fatty acids are what make Phosphatidylcholine valuable for promoting health. Phosphatidylcholine is important because it provides the body with choline which is required for the proper metabolism of fats as well as regulating the movement of fats in and out of cells. Choline is also need to maintain cell membrane integrity. Phosphatidylcholine also increases the solubility of cholesterol and hence decreases the chances of atherosclerosis.

Phosphollipid complex is formed by the combination of lipids and phosphate. They are grouped into three categories. 1. Glycerophosphates- Glycerophosphates are one of the important factors for cell membranes. They are also responsible for intracellular messaging and act as a hormone stimulant. 2 Sphingophosphatides- These phospholipids are responsible for transportation of water and fat soluble materials through cell membranes. It also helps to stabilize water soluble compounds. 3. Glycolipids. They help to maintain the structure of the cell membrane by attaching themselves with other components. Phospholipids complex is important for maintaining physiological activity of the body as they are an important factor for bonding and formation of enzymes, amino acids, etc.

Quercetin is a flavanoid derived from plants and is widely used as a nutritional supplement. There are many studies which are being conducted to exactly determine the benefits of Quercetin. It is said to have antioxidant and anti-inflammatory properties and hence is being tested to help curb and cure terminal diseases like cancer. The high intake of fruits and vegetables is good for cancer treatments. Many researchers believe that these qualities of Quercetin are what allow it to be used for treating cancer as well. Quercetin is classified into the IARC group 3; which categorizes food and drugs as that which are not carcinogenic.

Rhodiola Rosea Extract is the extract of a plant that grows in the cold regions of the world from the Crassulaceae family. It is considered to be dioecious, which is having both male and female parts. Rhodiola Rosea is an adaptogen and that is a natural herbal medicine that increases the body’s resistance to trauma, stress, fatigue, and anxiety. It improves the mood and can lessen the effects of depression. This extract supports the nervous system and helps to significantly boost mental functions by increasing blood supply to the brain. It can also normalize the heart rate after intense exertion. Combined with moderate exercise it can aid in significant weight loss because it activates hormone-sensitive lipase, which enables the breakdown of fat stored in adipole tissue. Fat stored in adipole tissue is normally very difficult to get rid of.

Ribonucleic Acid - Derived from yeast, Ribonucleic Acid (RNA) is an antioxidant and plays a vital role in protein synthesis, and other chemical activities of cells. It passes genetic information from DNA to proteins made by the cells. It enhances the capability to learn. RNA also helps treat Alzheimer’s disease and depression, and increases energy levels. It tightens the skin, enhances sex drive and helps in countering aging effects. It is also helpful in recovery after surgical procedures and helps boost immune system response. It assists in improving prognosis of burn victims. A supplement containing RNA can reduce the incidence of peri-operative infections and improve healing of wound. It can also be helpful in epilepsy.

Smilax- The genus Smilax includes approximately 300 different species of vines, found in warm regions like South America, North America and the Caribbean. Also known as Sarsaparilla, the roots of the plant are highly effective and thus used in various herbal treatments. For centuries, Smilax has been used by the natives for curing ailments and disorders like sexual impotence, dermatitis, syphilis to name just a few. The plant contains plant steroids called saponin as well as flavonoids. Theoretically, it is believed that the body synthesizes saponin into sex hormones, testosterone and estrogen. Since the plant has flavonoids, it also boasts of antioxidant properties. Smilax dietary supplements are extensively used for strength training and bodybuilding. The best benefit of using Smilax supplements is that there are absolutely no side effects.

Taraxacum Officinale, more commonly called Dandelion, is a bitter diuretic from the Asteraceae family of plants. It performs as a stimulant to the system, concentrated on the urinary organs. When combined with other medicinal herbal agents, it is useful in the treatment of liver and kidney disorders, gallbladder and urinary disorders, jaundice, constipation, cirrhosis, dyspepsia, weaknesses of the heart, eczema and chronic joint and skin problems. Dandelion is also a mild laxative and can be taken in large amounts because it is not poisonous. It promotes good digestion and also increases the appetite.

Trimeylxanthine Anyhydrous is a form of caffeine that is found in many energy supplements. This stimulant is very beneficial for those who are looking to increase their energy and stamina levels. Trimelyxanthine anyhydrous is often combined with other ingredients to create various proprietary blends that are sold as weight loss supplements or energy supplements. Trimelyxanthine anyhydrous may also be marketed as a supplement that will bring about greater mental clarity, mental alertness, and focus. You can find this stimulant in both pill form and more potent powder form, although not generally sold alone but found as an active ingredient in other products.

Vinpocetine, a derivative alkaloid of vincamine, is actually semi synthetic in nature. It is an extract from the It is an extract from the periwinkle vinca minor. Vinpocentine is used because it has neuroprotective effects and also helps in enhancing the cerebral blood flow. In Eastern Europe, it is also used as a drug to treat cerebrovascular disorders along with age related memory impairment. It is also extensively marketed as a supplement for vasodilation. It is also used to improve the memory since it plays the role of a nootropic. Vinpocentine is therefore used in supporting brain function. It helps in enhancing concentration and memory by activating cerebral metabolism. In the body building world, vinpocetine is often used a vasodilator. However, no research has been done so far on the effect of vinpocentine in the body building.

Vitamin B3, also called Niacin, is a water-soluble vitamin needed for the conversion of food into energy so that it may be used by the body. Vitamin B3 also helps metabolize protein, sugar and fat.