Beta-Hydroxy-Beta-Methylbutyrate or Calcium HMB is a metabolite of the essential amino acid leucine. It is naturally produced in human body and small quantities can also be found in grapefruit, alfalfa, and catfish. Calcium HMB is used as a supplement because research has shown it to Increase sarcolemmal integrity via conversion to HMG-CoA and to enhance protein synthesis. It also helps in depression of protein degradation through inhibition of the ubiquitin pathway. Calcium HMB is proved to help muscle formulation so it is given to patients with HIV or AIDS and trauma victims with severe injuries. It is also used in treatment of cancer.

Creatine Monohydrate supplements received wide popularization the early nineties of the twentieth century although already in the early years of the century proof existed that the muscle content could be boosted by the ingestion of creatine. The scientists discovered shortly thereafter the importance of creatine phosphate and the research did not stop there. While some weak supplements were available before 1992, with the introduction of Phosphagen into the supplement market, one of the most important products for the body building community has been created. Ever since then, creatine supplements have been changed and amended, improving the bioavailability and absorption properties. Currently there is a new version of the most popular supplement version, creatine monohydrate. Micronized creatine is this new product and it promises much quicker digestion and utilization.

L-Arginine - Several functions in our body are carried out by L-Arginine that is actually an amino acid. Its major advantage is to help the body get free of the waste product named ammonia. It also helps in the development of compounds such as L-proline, L-glutamate and creatine in the body. If required, it can also be converted into glycogen or glucose. The blood vessels in our body our relaxed by the compound named nitric oxide which is produced by the help of L-arginine. Another great advantage of L-arginine is the formation of protein in our body. Many other uses of L-arginine is found in the treatment of erectile dysfunction, healing of wounds, reducing high blood pressure and many more.

L-Citrulline refers to an amino acid that optimized the blood flow by converting into L-arginine and later on as nitric oxide. L-Citrulline includes L-arginine and L-ornithine. This assists in liver detoxification. The L-Citrulline is manufactured in the urea cycle. L-Citrulline promotes ammonia incorporation. L-Citrulline was initially separated from watermelon and this acquired the citrulline owing to the Latin word cirtrullus for watermelon. This amino acid is found in the dietary protein and plays a significant role in recycling Arginine and is also a significant factor in releasing nitric oxide. L-Citrulline is the main element to create Nitric Oxide and involves in amino acid catabolism. This is an energy source for microorganisms and is also employed as identifying test. Oral supplementation is available readily and recently studies have shown that Citrulline is the best cellular Arginine source and besides it also enhances energy. It also motivates the defense mechanism. The recommended dosage is one and quarter teaspoon daily.

L-Glycine- Glycine is an organic compound and one of the 20 amino acids deemed as building blocks for proteins. This proteinogenic amino acid is not only the smallest but also the only amino acid of the group that is not chiral, which means there is no enantiomer of glycine. With the prominent exception of collagen, which thirty five percent are glycine, most proteins contain only small amounts of it. As a solid, glycine is sweet tasting, crystalline and has no color. Despite being non-essential, because it can be biosynthesized from the amino acid serine, glycine has several important physiological functions, besides being a precursor to proteins. It is a biosynthetic intermediate of purines and the D-Aminolevulinic acid and it is an inhibitory neurotransmitter found in the central nervous system.

L-Ornithine is produced when the enzyme arginase reacts on L-arginine, whereby urea is being created. Consequentially, ornithine seems to be a vital part of the urea cycle, the disposal of ammonia and the removal of excess nitrogen. Although ornithine is not coded for by the DNA, which means that it is not a part of the protein synthesis processes. Despite this fact, the urea cycle plays a big part in arginine biosynthesis, which means that as an intermediate in a metabolic process, ornithine still retains vital importance. L-Ornithine is gaining on popularity as a nutritional supplement, in particular with the body building circles, where it is propagated as a muscle building and fat loss agent. It is furthermore stated that L-Ornithine may be initiating the release of growth hormones in the body.