5-HTP is short for 5-Hydroxytryptophan, which is an amino acid. As a transitional component in tryptophan metabolism, 5-HTP is also a compound which in the metabolic pathway precedes the monoamine neurotransmitter serotonin. As a dietary supplement, 5-HTP is suggested for use as an antidepressant, sleeping aid, but also as an appetite suppressant. Vitamin B6 helps 5-HTP decarboxylate into serotonin, with assistance of a lyase enzyme, namely the aromatic L amino acid decarboxylase. The theory is that 5-HTP, when ingested as a supplement, leads to increased serotonin production. While mainly being used as an appetite suppressant in the body building community, it also improves cognitive abilities, but also endurance and stamina. While there are some concerns in use of 5-HTP and MAO inhibitors in combination, sensitive users report only positive effects, that is why it was included in Gaba-V.

GABA or gamma-aminobutyric acid happens to be an inhibitory neurotransmitter in the brain that is crucial for our well being since it helps induce relaxation and sleep. As such, it performs the role of a balancer for the brain by balancing excitation of the brain with inhibition. There is more to GABA than its balancing effects. GABA has a major impact on muscle building and fat prevention due to its effect on HGH levels. GABA stimulates the anterior pituitary thereby increasing Human Growth Hormone (HGH) levels. HGH has anabolic and lipotropic properties and GABA thus indirectly causes these two positive effects in the body. However, people taking GABA supplementation may experience certain side effects that may range from tingling sensations around the face and neck area to mild change in breathing patterns or heart rate. Thankfully, these side effects are not harmful and subside quickly.

Valerian Root is a perennial plant, which can bloom into pink and white flowers that have a scent perceived as sweetly. It can be found in Europe and some areas in Asia, recently also in North America, where it has been imported. The sedative and anxiolytic properties of the valerian roots have been known to mankind for centuries. Valerian root extracts contain many pharmacologically active substances, some which are valeric acid, GABA, isovaleramide, valerine, valerianine, actinidine, an essential oil that contains sesquiterpenes, and many more. Since that valerian has been used as a pain reliever, anti convulsant, a sedative and for migraine treatment, the primary use has been always related to the GABA receptor system. It has been recommended as a potent sleeping agent.