Caffeine is a methylated xenthine discovered in 1819 by Friedrich Ferdinand Runge, a German chemist. Sources of Caffeine include beans, fruit and leaves of some plants. Caffeine available for human consumption is most commonly extracted from the coffee plant cherries and tea bush leaves, as well as foods and drinks that contain products derived from the kola nut. Caffeine can temporarily reduce the sensation of being tired; however, this does not mean that it eliminates the need for sleep. Generally, twenty five to fifty milligrams of caffeine is enough for most consumers to report an increase in alertness and arousal. Caffeine should be not be consumed by those with fecal incontinence as it relaxes the internal anal sphincter muscles.

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Glucuronolactone is actually short for glucuronic acid lactone, which is naturally occurring in the human body, namely in the liver. According to reports, the United States Government used Glucuronolactone to provide their soldiers in Vietnam with additional energy and a feeling of wellbeing. While there is no confirmation to these claims by the US Government, the characteristics of Glucuronolactone are true and therefore it is a very popular ingredient in energy drinks. Additionally, Glucuronolactone is a very important part of all connective tissues, and is also a known detoxing agent. Being a natural component of the human organism, it is a much better stimulant than caffeine, reducing sleepiness and fatigue, additionally improving concentration and overall mental performance. In Canada and some parts of Europe, Glucuronolactone is a controlled substance.